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 Archive

 December 2014

 Volume 1 Issue 1

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Editorial

Criteria for Referrals for Pediatric Hypertension:  The Fourth Report Revisited

Leonard C. Hymes*

The obesity epidemic in this country has had a profound effect on the health children within the last 20 years.Type 2 diabetes, cardiovascular disease, sleep apnea and hypertension have all increased in the pediatric population as a result of obesity. The incidence of hypertension alone has increased four-fold since the 1980s.  Even more remarkable, in 1988, secondary causes of hypertension accounted for 84% of referrals for hypertension to pediatric nephrologists. By 2010, this demographic had reversed with primary hypertension accounting for 90% of referrals,a change also attributed to the greater prevalence for obesity.

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Mini Review

Role of continuous renal replacement therapy in patients with acute respiratory distress syndrome treated with extracorporeal membrane oxygenation.

Bijin Thajudeen *, Santhosh G John, Saravanan Balamuthusamy and Amy Sussman

Extracorporeal membrane oxygenation (ECMO) is a modality of treatment used in the intensive care unit (ICU) to improve gas exchange in patients with acute respiratory distress syndrome (ARDS) and continuous renal replacement therapy (CRRT) is added to the treatment mainly for correction of fluid and electrolyte imbalance.                                                                                                 

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Editorial

Next Generation Sequencing and Kidney Disease: The New Era

C. Muller*

The decreased cost and increased speed of sequencing has made it possible to use large-scale genomic analysis as a clinical tool. Most of the known diseases–causing mutations occur in exons, which are the coding sequences for nctional proteins. This sequencing has facilitated an accurate diagnosis in individuals with disorders that present with atypical manifestations, which are difficult to confirm using clinical or laboratory criteria alone or otherwise require extensive or costly evaluation. Next generation sequencing (NGS) not only enables the detection of new genes and single-nucleotide polymorphisms (SNPs), which have important roles in human disease, but also provides a variety of information about what kinds of functions are associated with genes in these conditions.                                                                                                     

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Case Report

Long-term prognosis of patients receiving hemodialysis therapy in conjunction with regular continuous ambulatory peritoneal dialysis

Hiromichi Suzuki*

We previously reported that once-a week hemodialysis (HD) therapy in conjunction with regular continuous ambulatory peritoneal dialysis (PD) improved solute clearance and symptoms related to uremia in PD patients. Here, we describe a long-term follow up on a large cohort of PD patients receiving combination therapy with PD and HD. We analyzed 105 patients (average age: 55.1±11.8 years old; F/M: 31/74; duration of PD: 32.2±27.8 months) who were receiving PD and suffered from insufficient dialysis dose (weekly creatinine clearance of less than 45 L/week). Once-a week HD therapy was introduced between 2000 and 2009. Patients were observed for 5 years.                                                                                                 

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Case Report

Comparison of Nocturia Severity with Interquartile Range of Voided Volumes and Bladder Compliance in Men

Stephen D. Marshall MD, Johnson F. Tsui MD, Johnathan Khusid MS*, Jeffrey P. Weiss MD, Jerry G. Blaivas MD, J.L.H. Ruud Bosch MD

Patients with low bladder compliance [BC] often void at fixed volumes. We aim to explore the relationship between actual number of nightly voids [ANV], interquartile range of voided volume [IRVV], and BC to determine whether ANV is related to BC and whether IRVV may serve as a surrogate for BC.
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Research Article

Indication of Bone Scintigraphy in Asymptomatic Japanese Patients with Newly Diagnosed Prostate Cancer

Nobuki Furubayashi*, Takahito Negishi, ShintaroUra, Yoshiki Hirai, Kenichi Taguchi and Motonobu Nakamura

Currently, international guidelines consider bone scintigraphy redundant in low-risk patients due to the very low risk of metastatic disease. The aim of this study was to retrospectively assess the correlation between thediagnosis and presence of bone metastasis on bone scintigraphy in Japanese patients newly diagnosed with PCa.

 

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Case Report

Neonate with Respiratory Distress, Failure to Thrive, Pancreatic Insufficiency and Hyperkalemia: Pseudohypoaldosteronism; Not Cystic Fibrosis!

Kiran Kumar Lanka MD*, Hanaa Nik Rushdi MD, Mia Sethna MD, Karen Schmidt MD, Leonard Hymes MD, David Collier MD, Guillermo Hidalgo MD.

This is a case of a neonate who presented with respiratory distress and failure to thrive; and on further testing, was found to have hyperkalemia and pancreatic insufficiency. As he had respiratory distress and pancreatic insufficiency, he was evaluated for cystic fibrosis and found to have a  positive sweat chloride test. However, the cystic fibrosis  transmembrane conductance regulator (CFTR)  sequencing was negative for mutation. The hyperkalemia and hyponatremia prompted the work up for aldosterone defect. The adrenocorticotropic hormone (ACTH) levels were normal with elevation of aldosterone levels and plasma renin activity (PRA) which was suggestive of Pseudohypoaldosteronism (PHA).

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