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Current Edition

December 2017

Volume 4  Issue 1

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Research Article

Concurrent Chromosome 3p Mutations Are Associated With Worse Prognosis in Clear Cell Renal Carcinoma in an Institutional Cohort and the  Cancer Genome Atlas

Christopher G. Keith, Fei Lian, Shilpa Sreedharan, Priscilla E. Davidson, Kenneth Ogan, Viraj A. Master, John G. Pattaras, Kenneth J. Carney, Peter T. Nieh, Megan Yu, John Gaspar, Jeremy Goecks, David L. Roberts, Michael R. Rossi, Rebecca S. Arnold, John A. Petros*

In the United States, kidney cancer contributed to an estimated 63,920 new cases and 13,860 deaths in 2014, making it the 7th most deadly cancer in the country. Around 90% of such cases are renal cell carcinoma (RCC). Clear cell RCC (ccRCC) accounts for 70-75% of all RCC and around 90% of metastatic RCC cases. As such, the vast majorities of the cost, morbidity, and mortality associated with kidney cancer are due to ccRCC.

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Research Article

Renal Dyslipidemia and Cardiovascular Mortality Over Two Decades of Follow-Up

P-O Attman, M Petzold, O Samuelsson*

Cardiovascular disease (CVD) is common in patients with chronic kidney disease. With declining renal function the CKD patients develop characteristic alterations of the lipoprotein metabolism with accumulation of intact and partially metabolized triglyceride-rich lipoproproteins. These lipoproteins contain apolipoprotein C-III, which has been suggested to have a pathophysiological role in atherogenesis.

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Research Article

The Significance of Age Development Characteristics of Urethral Plate in Surgical Repair for Hypospadias

Liu Guoqing*, Zhang Shilin, Wang Jianfeng, Li Chunjing, Xie Xumin, Li Jierong, Liu shihui

Hypospadias is the most common external genitalia officer deformity in male children. Over the past three decades, the global incidence of hypospadias was on the rise and may be associated with endocrine disruptions in the environment. Surgery is the only way to treat hypospadias. The main steps include: Orthoplasty or penile straightening, Urethroplasty, Meatoplasty and Glanuloplasty, Scrotoplasty, and Skin Coverage.

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